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Allegra (fexofenadine) is effective at reducing symptoms for seasonal allergies and chronic hives without significant drowsiness, unlike Benadryl Allegra is the brand name of fexofenadine, an over-the-counter medication used to treat the signs and symptoms of allergies and hives Allegra is in Allegra D Pills a class of medications known as antihistamines. Can I take two allegra d 12 hour caplets in a 12 hour period… Customer Question. Com/allegra-d-side-effects-drug-center. Pseudoephedrine is a decongestant that shrinks blood vessels in 8. Taking Allegra-D with other drugs that make you sleepy or slow your breathing can worsen these effects. This combination medication is used to temporarily relieve symptoms caused by the common cold, flu, or allergies. 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